Drive assembly for a medicament delivery device

ABSTRACT

A power pack for use with a medicament delivery device is presented having a plunger rod movable along a longitudinal axis; a drive spring operably connected to said plunger rod; a plunger rod sleeve arranged with holding elements for releasably holding said plunger rod with said drive spring in a tensioned state. Signal initiating elements are arranged to said plunger rod; and signal generating elements arranged to cooperate with said signal initiating elements for providing information to a user of a medicament delivery device about the movement of said plunger rod when said plunger rod sleeve has been activated to release said holding elements.

CROSS REFERENCE TO RELATED APPLICATIONS

The present application is a continuation of U.S. patent applicationSer. No. 17/725,206, filed Apr. 20, 2022, which is a continuation ofU.S. patent application Ser. No. 16/098,542, filed Nov. 2, 2018, whichis a U.S. National Phase Application pursuant to 35 U.S.C. § 371 ofInternational Application No. PCT/EP2017/060471 filed May 3, 2017, whichclaims priority to Sweden Patent Application No. 1650616-4 filed May 6,2016. The entire disclosure contents of these applications are herewithincorporated by reference into the present application.

TECHNICAL FIELD

The present disclosure relates to a power pack for a medicament deliverydevice capable of providing energy for expelling doses of medicamentfrom medicament containers.

BACKGROUND

Many medicament delivery devices on the market have been developed forself-administration of medicament to users. Since many of these usersgenerally are not experienced in handling medicament delivery devicesand there often is an amount of anxiety and reluctance in theself-administration, especially regarding injection medicament deliverydevices, the developers of medicament delivery devices often try todesign them with a large degree of functionality as well as featuresthat conceal or minimize the exposure of e.g. injection needles.

Another problem often accompanied with medicament delivery devices forself-administration is the correct handling in order to ascertain thatthe user receives the full and intended dose of medicament as well as tominimize the risk of failures and even accidents. In that regard it isimportant that the device is easy to handle but also that the userreceives information both before and during use. For instance it isimportant that the medicament delivery device is not removed prematurelyfrom a dose delivery site, which may be a problem as such because of thediscomfort of using the device wherein the user wants to remove themedicament delivery device as soon as possible.

For this purpose a number of signalling or information providingsolutions have been developed, where many of these concern informationduring and/or at the end of a dose delivery sequence in order to providethe user when it is safe to remove the medicament delivery device.

Document U.S. Pat. No. 7,758,550 discloses a medicament delivery devicewith a signaling unit. The signalling unit comprises a catch rodconnected to a switch sleeve, and an engaging sleeve which surrounds thecatch rod and is axially and fixedly connected, e.g. latched with afirst latching element, to a piston rod.

At the start of the delivery movement, the catch rod and the engagingsleeve, provided with an engaging element, are drawn even further apart,such that the engaging element is moved over a section that is providedwith latching elements, such that the latching elements are respectivelypassed over by the engaging element. A brief clicking signal is emittedas each of the latching elements is passed over by the engaging element.

The drawback with the solution according to U.S. Pat. No. 7,758,550 isthat in order to provide the signal, a number of additional componentsare needed apart from the components that are normally present inmedicament delivery devices.

SUMMARY

In the present application, the term “distal part/end” refers to thepart/end of the device, or the parts/ends of the members thereof, whichunder use of the device, is located the furthest away from a deliverysite of a user. Correspondingly, the term “proximal part/end” refers tothe part/end of the device, or the parts/ends of the members thereof,which under use of the device is located closest to the delivery site ofthe user.

The aim of the present disclosure is to remedy the drawbacks of thestate of the art medicament delivery devices and to provide a medicamentdelivery device having a signaling function that is reliable, clearlyunderstandable and that minimizes the need and use of additionalcomponents.

The aim is solved by a medicament delivery device provided with thefeatures according to the independent patent claim. Preferableembodiments form the subject of the dependent patent claims.

According to the disclosure the power pack that is to be used with amedicament delivery device may comprise a plunger rod movable along alongitudinal axis, a drive spring operably connected to said plungerrod, a plunger rod sleeve arranged with holding elements for releasablyholding said plunger rod with said drive spring in a tensioned state.

These features are common in many different medicament delivery devicesthat use pre-tensioned drive springs for delivering doses of medicament.The activation of the power pack may be performed in many ways, manuallyautomatically or semi-automatically.

According to a preferable solution signal initiating elements arearranged on the plunger rod and there are further provided signalgenerating elements that are arranged to cooperate with the signalinitiating elements for providing information to a user of a medicamentdelivery device about the movement of said plunger rod when the actuatorsleeve has been activated to release said holding elements.

With this solution, the plunger rod is used directly for initiatingsignals to a user for informing him or her about movement of the plungerrod, which is a clear indication of a dose delivery operation. It is anadvantage to use the plunger rod more or less directly, which reducesthe number of components while providing additional functionalitybesides the dose delivery function.

According to one feasible solution, the signalling elements may comprisea number of protrusions arranged after each other along the longitudinalaxis. These protrusions may be produced directly on the surface of theplunger rod when manufactured. In this respect, the protrusions may bearranged with equal distance after each other. On the other hand, theprotrusions may instead be arranged with decreased distance after eachother in the proximal direction, or there could be a mix of the twodepending on the intended information to the user. For instance, equaldistance between the protrusions will result in a decreasing signalfrequency because the power from the spring will decrease as the dosedelivery sequence progresses.

On the other hand, a decreased distance between the protrusions may,with the same spring, create a constant signal frequency depending onthe balance between the decrease in force and decrease in distance. Afurther scenario is that the frequency increases at the end of a dosedelivery sequence, again depending on the balance between the force ofthe spring and the decrease in distance.

In order to provide distinct signals, the protrusions may be designedwith wedge-shapes. With this type of shape and when the signalgenerating elements may comprise mechanical flexible elements thatmechanically engage with said signal initiating elements for providinginformation, then a very clear and distinct signalling is obtained.

As an alternative to protrusions, a number of cut-outs may be arrangedalong the longitudinal axis of the plunger rod. further, in order tokeep the number of additional components as low as possible, the signalgenerating elements may comprise the holding elements of said actuator.With this solution, the holding elements will have a dual function inthat they first hold the plunger rod in the loaded state and then afterrelease of the plunger rod, generate the signals that indicate theprogress of the dose delivery operation.

In order to provide a good grip for holding the plunger rod, as well asproviding clear and distinct signals, the holding elements may comprisegenerally longitudinally extending, flexible, arms, where the arms maybe arranged with ledges designed to engage recesses of the plunger rod,which ledges are arranged to cooperate with the signal initiatingelements. Moreover, the signal generating elements may comprise aplurality of mechanical flexible elements placed after each other in thelongitudinal direction in at least one row. With this solution thenumber of signal generating elements is higher than the number of signalinitiating elements, .e. it requires only one protrusion for generatingsignals when passing and contacting the row of signal generatingelements.

With the solutions described above, the information may comprise audibleinformation as well as tactile information in that both sound andvibrations may be created by the signal generating elements cooperatingwith the signal initiating elements.

According to a further feasible solution of the power pack, it mayfurther comprise an actuator arranged coaxially outside the plunger rodsleeve, where the actuator is movable from a blocking position to arelease position. The movement of the actuator from the blockingposition to the release position may be rotatable and/or movable alongthe longitudinal axis.

These and other aspects of, and advantages with, the present disclosurewill become apparent from the following detailed description of thedisclosure and from the accompanying drawings.

BRIEF DESCRIPTION OF DRAWINGS

In the following detailed description of the disclosure, reference willbe made to the accompanying drawings, of which

FIG. 1 is a perspective view of a power pack according to thedisclosure,

FIG. 2 is an exploded view of the power pack of FIG. 1,

FIG. 3A is a cross-sectional view of the power pack of FIG. 1,

FIG. 3B is a cross-sectional view of the power pack of FIG. 1,

FIG. 4 is a cross-sectional view during activation of the power pack ofFIG. 1,

FIG. 5 is an exploded view of a second embodiment of a power pack,

FIG. 6 is a cross-sectional view of the power pack of FIG. 5,

FIG. 7 is an exploded view of a third embodiment of a power pack,

FIG. 8 is a detailed view of a plunger rod sleeve comprised in the thirdembodiment,

FIG. 9 is a detailed view of a plunger rod sleeve comprised in the thirdembodiment,

FIG. 10 is a cross-sectional view of the power pack of FIG. 7,

FIG. 11 is an exploded view of a fourth embodiment of a power pack,

FIG. 12 is a cross-sectional view of the power pack of FIG. 11,

FIG. 13 is a cross-sectional views of the power pack of FIG. 11,

FIG. 14 is an exploded view of a fifth embodiment of a power pack,

FIG. 15 is a detailed view of a signal generating mechanism of the powerpack of FIG. 14,

FIG. 16—is a cross-sectional view of the power pack of FIG. 14, and

FIG. 17 is a cross-sectional view of the power pack of FIG. 14.

DETAILED DESCRIPTION

A power pack 10 shown in the drawings is designed to fit into amedicament delivery device designed to deliver a dose of medicament to apatient or user. The power pack 10, FIGS. 1 and 2, comprises anelongated plunger rod 12 arranged to act on a stopper of a medicamentcontainer (not shown) for expelling a dose of medicament. The plungerrod 12 is arranged with recesses 14 on its side surfaces, two in theembodiment shown and placed on opposite sides of the plunger rod 12.Outside and coaxial with the plunger rod 12 is a plunger rod holder 16arranged. It comprises a generally tubular proximal part 18, whichproximal part 18 is arranged with holding elements 20 in the form ofarms that are flexible in the generally radial direction. The free endsof the arms 20 are arranged with radially inwardly extending ledges 22,which ledges 22 are arranged to fit into the recesses 14 of the plungerrod 12, for releasably holding the plunger rod 12. The free ends of thearms 20 are further arranged with radially outwardly directedprotrusions 24. The inner surface of the proximal part 18 of the plungerrod holder 16 is arranged with longitudinally extending ledges 26, whichledges 26 are configured to interact with longitudinal grooves 28 on theouter surface of the plunger rod 12, providing a rotational lock betweenthe plunger rod holder 16 and the plunger rod 12, yet allowinglongitudinal movement between them. Further, the plunger rod 12 isarranged with signal initiating elements 30 that in the embodiment shownare arranged as rows of wedge-shaped protrusions, which wedge-shapedprotrusions 30 are intended to interact with the inwardly extendingledges 22 of the arms 20 of the plunger rod holder 16 as will bedescribed.

The distal end of the plunger rod holder 16 is arranged with attachmentelements 32 that are designed to attach the plunger rod holder 16 to asuitable housing of the medicament delivery device. The distal end ofthe plunger rod holder 16 may then be arranged with an end cap 34 thatfits with the housing. A drive spring 36, FIG. 3, that in the embodimentshown is a compression spring is provided inside the hollow plunger rod12 between a distally directed surface 38 of a proximal end wall 40 ofthe plunger rod 12 and a proximally directed surface 42 of the end cap34, which is fixed in relation to the plunger rod holder 16. A guide rod44 is further arranged inside the drive spring 36 for preventingbuckling of the drive spring 36 during activation.

Outside and coaxial with the actuator is a generally tubular actuator46, which actuator sleeve will act as an activator of the power pack aswill be described. The actuator 46 is on its inner surface arranged withinwardly directed surfaces 48 that will function as blocking elementsfor the holding elements as will be described. Further the inner surfaceof the actuator 46 is arranged with longitudinally extending recesses50, in the embodiment two recesses 50, that are arranged on oppositesides of the inner surface. The outer surface of the actuator 46 isfurther arranged with guide ledges 52, where some sections of the guideledges 52 are extending longitudinally, and some sections are arrangedwith an inclination in relation to a longitudinal axis L.

The device is intended to function as follows. When the power pack 10 isin its powered, ready to use state, the plunger rod 12 is pushed intothe plunger rod holder 16 from the proximal end, tensioning the drivespring 36. The arms 20 of the plunger rod holder 16 then enter therecesses 14 of the plunger rod 12, thereby holding the plunger rod 12 inthe tensioned state. In order for the arms 20 not to flex out ofengagement with the recesses 14 of the plunger rod 12, the actuator 46is placed outside the plunger rod holder 16, whereby the outwardlydirected protrusions 24 of the arms 20 of the actuator abut the inwardlydirected surfaces 48 of the actuator 46, thereby preventing radialoutward movement of the arms, FIG. 3 a.

The power pack 10 is then assembled with a suitable housingaccommodating a medicament container, which in turn is provided with amedicament delivery member. When the power pack 10 is to be activated,preferably after a medicament delivery member has been placed at a dosedelivery site, such as an injection needle penetrating the skin of apatient or user, the actuator 46 is operated, functioning as anactivator. This is done by turning the actuator 46 in relation to theplunger rod holder 16. The turning may be performed in many ways, suchas by an activation button operated manually by a user or by amedicament delivery member guard that is contacting the dose deliverysite and is moved distally in relation to the medicament delivery deviceand the actuator sleeve. Appropriate elements may then cooperate withthe inclined guide ledges of the actuator 46 for providing a rotation ofthe latter.

The turning of the actuator 46 will cause the longitudinal recesses 50of the actuator sleeve 46 to be moved in line with the arms 20 withtheir outwardly directed protrusions 24, FIG. 3b . This releases thearms 20 so that they can flex outwards whereby the inwardly directedledges 22 will move out of engagement with the recesses 14 of theplunger rod 12. The plunger rod 12 is now urged in the proximaldirection by the force of the drive spring 36 whereby the plunger rod 12will act on the stopper of the medicament container such that a dose ofmedicament is delivered.

During the movement of the plunger rod 12 in the proximal directionduring the dose delivery sequence, the inwardly directed ledges 22 ofthe arms 20 will be in contact with and slide along the plunger rod 12,FIG. 4. The ledges 22 will then come in contact with the rows ofwedge-shaped protrusions 30 and will move along these, causing arattling sound as well as vibration, i.e. audible and tactileinformation to the user during the dose delivery sequence. Thelongitudinal ledges 26 on the plunger rod holder 16 cooperate with thegrooves 28 on the plunger rod 12 for preventing the plunger rod 12 fromturning during the movement, which otherwise would risk that the ledges22 of the arms 20 would be moved out of engagement with rows ofprotrusions 30.

In the embodiment shown, the row of wedge-shaped protrusions 30 extendsalong a majority of the length of the plunger rod 12. It is however tobe understood that the row of protrusions 30 may be arranged such thatthey engage with the ledges 22 of the arms 20 only at the end of a dosedelivery sequence or during the latter half of the dose deliverysequence for just informing the user that the dose delivery sequence isabout to terminate. It is of course to be understood that the signallingelements may have other shapes for creating the desired signaling to auser. Also the length between each subsequent protrusion, and thus thefrequency of the sound, or vibration, may be modified in order to varythe signaling. In this respect the frequency may be altered during thedose delivery sequence, e.g. increasing the frequency during theprogress of the dose delivery sequence.

A second alternative is shown in FIGS. 5-6. Here the signal initiatingelements comprise at least one row of cut-outs 60 along the plunger rod12 ^(II). The signal generating elements are here arms 62 that areflexible in the generally radial direction and directed proximally. Thefree ends of the arms 62 are arranged with inwardly directed protrusions64 that will engage the cut-outs 60. The signal generating elements 62are attached to or made integral with a generally tubular and elongatedplunger rod sleeve 66. He outer surfaces of the arms 62 will cooperatewith an actuator 46 ^(II) for releasingly holding the arms and therebythe tensioned plunger rod 12 ^(II). Moreover, there could be a secondrow of cut-outs 60 ^(II), for example on the opposite side of theplunger rod 12 ^(II). This could be used for creating a more frequentsound generation wherein one row is displaced half a step in the axialdirection. With this solution the sounds appear twice as many times.

Further in order to ensure the relative positions between the row orrows of cut-outs and the protrusions on the arms, the plunger rod 12^(II) is arranged with a number of laterally extending protrusions orwings 68, which wings fit into longitudinal guide slots 70 in theplunger rod sleeve 66. The guide slots 70 are further preferablyarranged with stop surfaces 72 at a proximal area of the plunger rodsleeve 66. This ensures that a tensioned plunger rod 12 ^(II) cannotshoot out of the plunger rod sleeve 66 during assembly of the powerpack.

Further, even though it is an advantage to use the arms of the plungerrod holder not only for holding the plunger rod, but also to create theinformation to the user, in some instances there could be separateelements that are in contact with the rows of protrusions, causing thesound and the vibrations.

This variant is displayed in FIGS. 7-10 that show a third embodiment ofa power pack. As with the second embodiment, a plunger rod 12 ^(III) isprovided with a number of signal initiating elements in the form of anumber of cut-outs 80 placed in rows in the longitudinal direction ofthe plunger rod 12 ^(III), in the embodiment shown two rows of cut-outs80 placed on opposite sides of the plunger rod 12 ^(III). The plungerrod 12 ^(III) is arranged to slide in a plunger rod sleeve 82. Moreover,the plunger rod sleeve 82 is arranged with proximally directed signalgenerating elements in the form of proximally directed arms 84, FIGS. 8and 9, which arms 84 are provided with inwardly directed protrusions 86that are to interact with the cut-outs 80 of the plunger rod 12 ^(III)for creating sound during movement of the plunger rod 12 ^(III). Incontrast to the previous embodiment, the plunger rod sleeve 82 isprovided with a separate set of arms 88 that are directed in the distaldirection and that are flexible in the generally radial direction. Thefree ends of the arms 88 are provided with inwardly directed ledges 90,which ledges 90 are designed to interact with certain cut-outs 80 ^(I)in the rows of cut-outs 80 of the plunger rod 12 ^(III). The ledges 90are arranged to hold the plunger rod 12 ^(III) with a drive spring 36tensioned as seen in FIG. 10.

The outer ends of the arms 88 are arranged with protrusions 92 that areto interact with an actuator 93 that in the embodiment shown has atubular body 94 with two distally directed arms 95 slidable inside ahousing 96 of a medicament delivery device. When the proximal end of thehousing 96 with its extended actuator 93 is pressed against a dosedelivery site, the actuator 93 will move in the distal direction and thedistal ends of the arms 95 will act on the protrusions 92 and move thearms 88 of the plunger rod sleeve 82 outwardly for releasing the plungerrod 12 ^(III). Moreover, the distal end of the plunger rod 12 ^(III) isprovided with a number of outwardly directed guide elements 98, whichguide elements 98 are designed to fit into longitudinally extendinggrooves 99 of the plunger rod sleeve 82 for preventing rotation of theplunger rod 12 ^(III) in relation to the plunger rod sleeve 82.

FIGS. 11-13 show a fourth embodiment of a power pack. In this embodimenta plunger rod sleeve 100 is arranged with two proximally directed arms102 that are flexible in the generally radial direction. The free endsof the arms 102 are arranged with inwardly directed protrusions 104,FIG. 13, which protrusions 104 fit into recesses 106 of a plunger rod 12^(IV) that is slidable inside the plunger rod sleeve 100 for holding theplunger rod 12 ^(IV) in a tensioned state by a drive spring 36. The arms102 cooperate with an actuator 46 ^(IV) in the same manner as describedabove.

The plunger rod sleeve 100 is further arranged with signal generatingelements in the form of a plurality of proximally directed arms 108 thatare flexible in a generally radial direction. The free ends of the arms108 are arranged with inwardly directed protrusions 110. The pluralityof arms 108 is placed in rows after each other in the longitudinaldirection of the plunger rod sleeve 100. In the embodiment shown, thereare two rows of arms 108 that are placed on opposite sides. Theplurality of arms 108 of the signal generating elements is to cooperatewith signal initiating elements that are in the form of outwardlydirected protrusions 112 on a distal area of the plunger rod 12 ^(IV).The protrusions 112 are placed such that when the plunger rod 12 ^(IV)is released, the protrusions 112 will come in contact with the inwardlydirected protrusions 110 of the arms 108 of the signal generatingelements, causing an audible feedback that the plunger rod 12 ^(IV) ismoving, e.g. during a dose delivery sequence. As with the previousembodiment, if more than one row of arms 108 is used, one row may beplaced offset half a step in relation to the other row, creating ahigher frequency of the sounds generated.

FIGS. 14-17 show a fifth embodiment of a power pack. As with some of theprevious embodiments, a generally tubular plunger rod sleeve 120 isprovided with proximally directed arms 122 that are flexible in agenerally radial direction. The free ends of the arms 122 are providedwith inwardly directed protrusions 124, which protrusions 124 aredesigned to fit into cut-outs 126 in a generally elongated plunger rod12 ^(V), for holding the plunger rod 12 ^(V) in a tensioned state with adrive spring 36. Also here, an actuator 46 ^(V) is arranged forinteracting with the arms as described above. The proximal end of theplunger rod sleeve 120 is provided with a seat 128 in which a metal clip130, FIG. 15, can be attached. The metal clip 130 is bent with a certainshape so as to have two arc-shaped sections 132 integrated with inwardlyinclined legs 134, which in turn transform into flat sections 136 thatattach to the seat. The design provides a flexing action of thearc-shaped sections in a generally longitudinal direction, where theintention is for the arc-shaped sections to be in contact with a distalend of a syringe or the like medicament container for providing abiasing force on the medicament container, thereby minimizing anyrattling or movement of the medicament container. In addition, the flatsections 136 are provided with inwardly extending and proximallyinclined tongues 138 that constitute signal generating elements.

Further, the plunger rod 12 ^(V) is arranged with a plurality ofcircumferentially extending, wedge-shaped, protrusions 140, being soundinitiating elements. Thus, when the plunger rod 12 ^(V) is released andis moved in the proximal direction by a drive spring 34 for performing adose delivery sequence, the inclined tongues 138 will be in contact withand be tensionally biased by the passing wedge-shaped protrusions 140,hitting subsequent protrusions when leaving previous protrusions,causing tactile and audible information to the user of the ongoingsequence. Since the wedge-shaped protrusions 140 are positioned aroundthe whole circumference of the plunger rod 12 ^(V), there is no need forguiding elements that orientate the plunger rod 12 ^(V) in relation tothe signal generating element, i.e. the tongues 138.

It is to be understood that the embodiment described above and shown inthe drawings is to be regarded only as a non-limiting example of thedisclosure and that it may be modified in many ways within the scope ofthe patent claims.

1. A notification mechanism positioned within a medicament deliverydevice, where the notification mechanism comprises: a tubular proximalpart comprising a central opening and an inwardly extending ledge thatprojects radially into the central opening; and an assembly comprising aplunger rod and a drive spring, where the assembly is movably positionedwithin the central opening such that a row of signal initiating elementspositioned longitudinally along the assembly slidably engage theinwardly extending ledge, and wherein the signal initiating elementsslidably engage with the inwardly extending ledge during relative axialmovement between the assembly and the tubular proximal part such that atactile or audible signal notification is provided to a user of themedicament delivery device.
 2. The notification mechanism of claim 1,wherein the inwardly extending ledge is part of a flexible arm.
 3. Thenotification mechanism of claim 2, wherein the flexible arm generallyprojects proximally along a longitudinal axis of the assembly.
 4. Thenotification mechanism of claim 1, wherein the tubular proximal partfurther comprises two inwardly extending ledges diametrically positionedaround the central opening such that both inwardly extending ledgesproject radially into the central opening.
 5. The notification mechanismof claim 2, wherein the flexible arm flexes radially outward as theassembly moves in a proximal direction during engagement with the signalinitiating elements.
 6. The notification mechanism of claim 1, whereinthe inwardly extending ledge is formed as an integral part of thetubular proximal part.
 7. The notification mechanism of claim 1, whereinthe row of signal initiating elements comprise a plurality ofalternating recesses and protrusions.
 8. The notification mechanism ofclaim 1, wherein the signal initiating elements are equally spaced inthe row to provide a constant notification frequency of the tactile oraudible signals.
 9. The notification mechanism of claim 1, wherein thesignal initiating elements are unequally spaced in the row to provide avariable notification frequency of the tactile or audible notificationsignals.
 10. The notification mechanism of claim 9, wherein the variablenotification frequency provides notice to the user that a medicamentdelivery sequence is progressing.
 12. The notification mechanism ofclaim 1, wherein the inwardly extending ledge is formed at the end of aflexible arm that is shaped to snap into and out of the signalinitiating elements during a medicament delivery sequence.
 13. Thenotification mechanism of claim 1, wherein the user is notified at anend of a medicament delivery sequence.
 14. The notification mechanism ofclaim 1, wherein the tubular proximal part is axially fixed relative tothe assembly such that the inwardly extending ledge only moves radiallyoutward and radially inwardly as the assembly moves axially in theproximal direction.
 15. The notification mechanism of claim 1, whereinthe notification mechanism further comprises a spring that causes therelative axial movement between the assembly and the tubular proximalpart.
 16. A medicament delivery device comprising: an outer housinghaving a longitudinal axis; and a notification mechanism comprising: atubular proximal part having a central opening and an inwardly extendingledge that projects radially into the central opening; and an assemblycomprising: a drive spring having a biased state and a released state; aplunger rod positioned within the central opening; and a row of signalinitiating elements projecting along the longitudinal axis; whereinengagement of the inwardly extending ledge with assembly during relativeaxial movement between the assembly and the tubular proximal partproduces a tactile or audible signal notification to a user of themedicament delivery device during medicament delivery.